Endocrine Abstracts

We describe the case of a 39-year-old lady who was diagnosed with acromegaly in 1997 with basal GH 89.9 mu/l with paradoxical rise to 152 mu/l on OGTT, her IGF-1 was 76 nmol/l refrange (9.5–45). She underwent transphenoidal hypophysectomy in 1998 for pituitary microadenoma and postoperatively her growth hormone level was 5 mu/l. Six months following surgery she had an OGTT during which she suppressed her growth hormone levels to a nadir of 5 mu/l and her IGF-1 was 46.1 nm...

A 54-year-old Afro–Carribean woman developed worsening obesity, hypertension, and proximal muscle weakness. Clinical examination revealed cushingoid facies, truncal obesity (BMI 34.8), abdominal striae and a BP of 150/90, Ferriman–Gallway score 12.Investigations:- FBG 10.7 mmol/l, 24 urine cortisols 147 mmol/l, 207 mmol/l (NR 25–280 nmol/24 h), normal short synacthen test (cortisol 471 rising to 1002 nmol/l). Subsequent testing revealed a ...